Cancer is a major public health problem worldwide. Breast cancer considered to be the most common cancer among females in the world and in Jordan as well. The first choice to treat breast cancer is surgery. Lymphedema is considered the most common complication may face females after mastectomy. There were different modalities to manage lymphedema. Therefore the purpose of this study was to review studies that address the effect of home based exercise on lymphedema among post mastectomy Jordanian females. A literature search was started using computerized databases of Google scholar, CINAHL, MEDLINE, and PubMed. The key words used to find the related articles were: Lymphedema, exercise, post-mastectomy and physical activity. The results of this studies give a clear evidence about the effectiveness of the home based exercise on lymphedema reduction, which may increase attention of health care providers to the importance of the home based exercise and to consider it as one of lymphedema treatment modalities.