Leprosy is still a significant public health problem, particularly in Indonesia. It caused medical, social, economic, cultural, and even political impacts. Disability caused by leprosy may influence a patient’s personality and reduce their self-confidence. It will inflict medication or a healing process. Thus it can increase the risk of disability. This study aims to learn the risk of disability among leprosy patients in Pamekasan District, East Java province. This is an analytic observational study with a case-control design. Data was collected using a questionnaire and Multiple Drug treatment (MDT) medical records. Thirty (30) leprosy patients with disabilities were taken as the case group, while the unmatched control was leprosy patients without disabilities