Solid waste Management is one of the serious issues looked by developed nations everywhere on the world. To control the solid waste to be inappropriate removal, the initial step is to do squander portrayal contemplates. In this paper, it is accounted for the after effects of a waste portrayal study were carried out in Sirkali, Mayiladuthurai district, TamilNadu. It was tracked down that the sirkali zone produces 1.2 Metric ton of strong squanders each day, more than 48 % of these squanders are recyclable. The innovation of anaerobic assimilation of natural strong squanders is utilized in numerous conditions without oxygen. In this paper, an endeavour has been made to give an extensive audit of the treatment advances to digest the MSW using anaerobic reactor with two different inoculums. The OSW is mixed with different inoculums such as cow dung, Sheep Manure, Pig Manure and sewage sludge.I tried with different ratios with different inoculums in layer filling for find out the better gas generation rate and volume reduction.The methane substance of the biogas made from the reactors was in the extent of 45–60% in control reactor and that for RC(100% OSW), R1 (90% OSW + 10% inoculums), R2 (80% OSW + 20% inoculums), R3 (70% OSW + 30% inoculums) were 58-63%, 63-77%, 65-78% & 61-68% respectively. Around the completion of the 21days handling of about 243 ml/g VS biogas was made. Unusual solid degradation was 39.50%, 43.75%, 48.51% and 54.55% were achieved during the digestion in Bench scale reactors RC, R1, R2, R3 respectively. The best Ratio of inoculums was found to be CD and SM to be added in layers with OSW to be digested in AD process in Main reactor and found the cumulative gas collection of 3819 ml/g VS and variation in PH for 75 of retention time.