This study aimed to assess the impact of the Mediterranean diet (Med-Diet) on sexual function in women diagnosed with metabolic syndrome (MS). Subjects and Methods: The study was conducted as a randomized controlled trial. Herein, 200 female patients diagnosed with MS and between 35 and 40 years of age and experiencing sexual dysfunction were randomly assigned into two equal groups. The control group (A) was on Kegel exercise sessions three times/week for 12 weeks, while the study group (B) had a combination of Kegel exercise and a Med-Diet regimen for the same 12-week duration. Two questionnaires were used for all female participants in both groups before and post-treatment; the female sexual function index (FSFI) questionnaire was used to assess sexual function, while the women's sexual quality of life questionnaire (SQOL-F) was used to assess the quality of life (QoL). Results: Our post-treatment findings showed a significant elevation in the FSFI questionnaire score in group B (M = 18.57, SD = 6.73) compared to group A (M = 15.87, SD = 6.98), with Z- and p-values of -3.805 and 0.001, respectively. Furthermore, the results indicated a significant increase in the SQOL-F questionnaire score in group B (75.05 ± 4.21) compared to group A (58.40 ± 11.95), with a statistically significant Z- and p- values of -9.763 and 0.001, respectively. Conclusions: The combination of a Med-Diet regimen and Kegel exercise is more efficacious than Kegel exercise alone in enhancing sexual function and quality of life among women diagnosed with MS.