Background: Mental disabilities is characterized by below average intelligence or mental ability and lack of skills necessary for day to day living. Mental disabilities children had self-care deficiency. Self-care required for meeting activity daily living. Aim of study: The aim of this study is to evaluate the effect of nursing guidelines for mother on improving self-care activities among mentally disabled children. Design: A quasi-experimental design was utilized in this study. Setting: Data was collected from the School of Intellectual Education in Shibin- Elkome, Menoufia Governorate. Subjects: The study was conducted on purposive samples of 150 MD children and their caregiver who attend for each child