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ISSN 2063-5346
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EFFECT OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL THERAPY IN TYPE2 DIABETES MELLITUS - A REVIEW

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Shanmugapriya.S.K1 , Shashank.K1 , Subashini.S1 , Sujitha.G.S1 , Ashok Kumar.T.R* ,Dr. Karthikeyan. K3 , Dr. Shanmugasundaram. P
» doi: 10.31838/ecb/2023.12.s1-B.478

Abstract

Diabetes Mellitus is a complex metabolic disorder that is characterised by hyperglycemia and impaired insulin secretion, with or without insulin resistance. Polyuria, Polydipsia, Polyphagia, fatigue, and Weight loss are the most common clinical manifestation of Diabetes Mellitus. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, and pancreas) insulin sensitivity. In type 2 diabetes, either the body does not produce enough insulin or the cells ignore the insulin. It usually begins as insulin resistance, a disorder in which the cells do not use insulin properly. As the need for insulin rises, the pancreas gradually loses its ability to produce it. Diabetic Ketoacidosis, Hyperosmolar Hyperglycaemic State, CVD, Nephropathy, Retinopathy, and Neuropathy are some of the complications that are experienced due to the chronic progression of the disorder. Treatment for people with diabetes includes Medical Nutritional Therapy (MNT), physical activity, weight loss, Oral Anti-Hyperglcaemic Agents (OHA) and Insulin therapy where ever required. Medical Nutritional Therapy is the diet plan that is framed to achieve euglycaemia in patients by considering their lifestyle and their preferences. Insulin therapy includes consideration of insulin based on the patient’s requirement to achieve euglycaemia. Pharmacological therapy includes treatment with OHA drug classes like Biguanides, Sulphonylureas, Meglitinides, Thiazolidinediones, Alpha-glucosidase Inhibitors, DPP-4 Inhibitors, SGLT-2 inhibitors. Euglycaemia can be achieved by proper combination of pharmacological therapy, Medical Nutritional Therapy with necessary lifestyle modifications.

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