The purpose of this research is to find an alternative to chemically manufactured drugs such as antibiotics used in the treatment of bactria infections, through nanotechnology manufactured from plant sources (green manufacturing), which is characterized by abundance and low economic cost, as well as having an effective inhibition of multidrug-resistant Klebsiella pneumonia isolated from children growth. These experiments were carried out in the laboratories of the College of Science, Department of Ecology from September to January 2022 -2023. Silver nanoparticles were synthesized using the crude aqueous extract of Schanginia aegyptiaca, and their properties were diagnosed. Field emission scanning electron microscopy (FE-SEM) was used to determine the surface, shape and compositional size of biosynthetic silver nanoparticles. The results showed that the sizes of nanoparticles ranged between 56.89 - 87.78 nm. The atomic force microscope was used to find out the shapes, topography, roughness and protrusions of the surfaces of the silver nanoparticles, as the average roughness of the nanoparticles was 71.44 nm. The X-ray diffraction (XRD) test was used to measure the size and crystalline nature of the above materials, as the average size of the silver nanoparticles was 75.03 nm, and these sizes were calculated according to the Debye-Sparker equation. Atotal of ninty five children patients suffering from asthma were enrolled in current study, sputum samples were collected and cultured according to standard methods.11(11.6 %) isolates of K.Pneumoniae were isolated and identified based on its cellular, cultural and biochemical characteristics. The activity of 20 antibiotics were detected against the current isolates by using Kirby Bauers disk diffusion method, the results showed high degree of resistance for most antibiotics by present isolates.The impinem,meropenem, siftrixone,azethromycin ,ciprofloxacin and amikacin were found more effective. In the present study, seven antibiotics were tested for minimum inhibitory concentrations (MICs)of isolates were higher level.