Background: non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is highly associated with several components of metabolic syndrome, particularly obesity, increased plasma lipid levels, glucose intolerance, and type 2 diabetes mellitus (T2DM) with insulin resistance (IR) and may progress to NASH and liver cirrhosis. Objective: investigating the effect and possible underlying mechanisms of Pitavastatin on the progression of NAFLD in rats fed on high fat high fructose diet. Material and Methods: forty male albino rats weighing (100-120) grams of local strain were used. Then, induction of NAFLD occurs by maintaining rats on high fat high fructose diet for 2 months followed by administration of pitavastatin with different doses. Then serial laboratory investigations including lipid profile, liver enzymes, oxidative stress and anti-oxidant markers were measured at the end of the experiment. Then, histopathological study of the liver were done Results: pitavastatin significantly ameliorate increases in serum SGOT, SGPT, lipid profile , hepatic steatosis, oxidative stress, inflammation , expression of cytokines through significant decrease in TNF- alpha, CRP, MDA, visceral fat index and also, significant increases in adiponectin and hepatic GPx.