The present study was carried out to evaluate the effect ethanolic extract of Punica granatum (P. granatum) Peel on forced swim test and Chronic cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like Glucose, Cholesterol, Triglycerides, Plasma cortisol and Blood urea nitrogen (BUN), In cold stress ulcer index, PH of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of 200,400 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH of gastric juice was observed compared to control group. Thus the obtained results revealed that the extract of P. granatum peel has got a significant anti-stress activity.