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ISSN 2063-5346
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SYNTHESIS OF TRIAZOLE AND OXADIAZOLE DERIVATIVES OF 6-METHYLBENZOTHIAZOL-2-YL – HYDRAZINE AND EVALUATION OF THEIR ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITIES

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Dr. N. Jayalakshmi, Dr. W. Shanthi, Dr. I. Syed ahamed hussain, Dr. S. Balasubramanian
» doi: 10.31838/ecb/2023.12.6.221

Abstract

Several triazole derivatives of 6-methylbenzothiazol-2-yl – hydrazine was synthesized by the cyclization of the acid hydrazides with CS2 in KOH followed by treating it with hydrazine hydrate and benzaldehyde. The chemical structures were valid with the help of ability of infrared spectroscopic analysis proton nuclear resonance spectroscopic analysis carbon -13 nuclear magnetic resonance spectroscopic analysis and mass bauer spectroscopic analysis. The resulted compounds are assessed for analgesic, anti-inflammatory drug, opposing microorganism and opposing fungous activity. Triazole subsidiaries was found to possess good analgesic and antiinflammatory properties. The oxadiazole subsidiaries showed against bacterial and hostile to fungous exercises. Likewise, the hindrance impact can increment with the enhance in concentration of those mixtures.

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