Background: External fixators are golden methods in controlling fractures however, a key drawback to its use is high incidence of pin-tract infection with estimated rates between 9 and 100%. Aim of the study: was to evaluate the effect of safety measures precautions on pin tract infection and disability among orthopedic patients with external fixation Subjects and Methods: Research Design: A quasi experimental design was utilized in this study. Setting: The study was conducted in orthopedic departments at Accidents hospital and Outpatient hospital at Zagazig University Hospitals. Subjects: Purposive sample of 40 orthopedic patients with external fixation divided into two groups each group consisted of 40 patients. Tools of data collection: four tools were utilized for data collection: patients' interviewing questionnaire, Checketts-Otterburn Grading System of pin site infection, Safety measures precautions, and ADLs-brief-disability-questionnaire. Results: revealed that more than half of patients aged below 30 years, more than three quarter were male, there was increase in patients’ knowledge, self-care practice, and safety measures, there was decrease in infection, and disability rates post intervention and in follow up compared to pre intervention. There was a statistically highly significant difference in relation between adequate safety measures and medical diagnosis, there was statistically highly significant positive correlation between knowledge with (self-care practice and safety measure). while there were negative correlations between each of (knowledge, self-care practice and safety measures) with each of (infection, and disability). Conclusion: safety measures precautions significantly improved patients’ knowledge, practice, pin tract infection, and disability among orthopedic patients with external fixation. Recommendations: safety measures should be included in routine nursing care and patient education.