In order for people with Guillain-Barre syndrome (GBS) to resume their independent daily lives as they did before the start of GBS, it is crucial to enhance their physical function. Objective: TO enhance Guillain-Barre syndrome patients' ability to carry out everyday activities, chest expansion, pain, and muscular strength. Subjects and methods: Twenty four adults with consistent residual impairment who were divided randomly into two equal groups six months following the beginning of GBS. In the experimental group, 60-minute sessions of task-oriented training (respiratory exercises, rocker board training, sit-to-stand training, walking five steps, up and down stairs, gait training, and foam roller massage) were assigned; in the control group, three sessions per week for a year of treatment (strengthening exercises, range-of-motion exercises, stretching exercises, and pain management) were administered. The Barthel Index was used as the primary endpoint to gauge functional independence in daily living activities, a visual analogue scale for pain intensity, muscle strength was assessed using the Medical Research Council scale, and fatigue was assessed using the Fatigue Severity Scale. Results: following 6 months, the median between-group difference was 3 (95% CI 2 to 4) for functional independence, while it was 7 (95% CI 7 to 7.5) for muscle strength, it was 16 (95% CI -19 to -12) for fatigue, it was 4 (95% CI 0.4 to 7) for the environment domain of quality of life, as well as it was 0.8 (95% CI 0.6 to 0.7) for chest expansion. The Estimated effects following 12 months had the same magnitude, and the majority of CIs had higher levels of uncertainty. Conclusion: Task oriented approach improves activity of daily living, reduced fatigue and improved strength in patient with GBS.