Background: Breastfeeding offers a lot of benefits to both the mother and infant. The World Health Organization (WHO) even recommended breastfeeding as an effective way in promoting infant nutrition. However, despite of advancing medical technology, breastfeeding practice is continually declining in Saudi Arabia as caused by a variety of factors , breastfeeding (BF) describes infants who were only breastfed for 6 months. Many Saudi mothers have suboptimal breastfeeding practices. Therefore Information about maternal knowledge and attitude toward exclusive breastfeeding (EBF) attitude is consequential to the actualization of the goals of the baby-friendly initiative and Millennium Development Goals (MDGs) 4 and 5. Aim of the study: To assess the effected of Knowledge and Attitude of Breast-feeding among Mothers Attending Primary Health Care Centers at Saudi Arabia 2022. Methods: cross- sectional study was conducted in Saudi Arabia among a sample of mothers, of any nationality who have a child aged between 2 and 24 months, attending the primary health care centers for well-baby services throughout the study period (October-September, 2022). An Arabic questionnaire was utilized for collecting data. It included four main sections: demographic characteristics and determinants, knowledge about breast feeding, attitude toward breastfeeding our sample 400 participant. Results: show the remaining socio-demographic characteristics of the patients. Their age ranged between <29 and >35 years, majority of participants <29 years were(37.0%), education most of participant intermediate school were (37.0%), regarding the child order in the family most of participant first l were (35.0%), regarding the number of children most of participant more than 4 children were (74.0%), regarding the nature/Type of Delivery most of participant Surgical operation were (75.0%) while normal delivery were (25.0%) .Conclusion: This study was conducted to determine the knowledge on breastfeeding among mothers who attended a well-baby clinic in primary health care centers in Saudi Arabia. Most participants have average knowledge concerning breastfeeding benefits for both mother and infant and disagreed on the mentioned barriers for EBF that include lack of breast milk, deficiency of information, and working conditions