The current study aims to investigate whether combined ABG and EMD treatment of angular bony defects in chronic periodontitis patients results in better clinical, radiographic, and biochemical outcomes than OFD treatment alone. Methodology: This parallel, controlled, prospective, and randomised clinical trial compared two potential treatments for angular anomalies. ABG combined with EMD used to treat the faults in the test group whereas OFD was used to address those in the control group. Ten defects were assigned to each group because certain issues can go away during the follow-up period. With a mean age of 44.17 ± 7.80 years and 12 chronic periodontitis patients (6 men and 6 women) were reported, between September 2021 and September 2022, with 20 defects equally allocated to both group. Results: All treatment modalities resulted in statistically significant improvements at six months (P< 0.01). The use of EMD—either with ABG or alone—was observed to induce significantly less recession than the OFD (P <0.05), while the combination and EMD groups demonstrated significantly better increases in attachment level (P< 0.01) and radiographic defect fill (P< 0.05) than the control group. Conclusion: The findings show that there are no clinical or radiographic differences between the combination and EMD groups, but that EMD has a beneficial effect on the amount of GCF TGF-1, which rises during the healing period.