Background: Coronary artery disease is caused by deposition of cholesterol and fats in the inner lining of coronary arteries which leads to blockage of it and obstruct the flow of blood to heart muscles which lead to ischemia and necrosis of muscles of the heart. Angioplasty is one of the interventions for management of coronary artery disease. Objectives: The objective of the study was to prepare discharge plan for post angioplasty patients and give them so they can take care of themselves at home and to evaluate its effectiveness on self-care practices of post angioplasty patient. Methodology: Quantitative research approach with quasi experimental time series design was adopted; total 52 post angioplasty patients were selected by using purposive sampling technique. Data was collected by using demographic Performa, self-care practice checklist. Discharge summary containing instructions regarding home care was given at the time of discharge from the hospital. Results: Results showed that Discharge plan was effective in improving the self-care practices of post angioplasty patients in all the domains of medication, diet, exercise, rest and sleep, stress management and smoking and alcohol. (F = 60.360, P < 0.000). Conclusion: This study concluded that discharge plan was effective in enhancing self-care practices of post angioplasty patients in the areas of medication, diet, exercise, stress management rest and sleep.