The choice between disposable and reusable medical tools in hospital settings has implications for infection control and quality of service. This systematic review aimed to evaluate the effectiveness of disposable versus reusable medical tools in these outcomes. A comprehensive search of relevant databases was conducted to identify studies evaluating the infection control and quality of service outcomes associated with disposable and reusable medical tools. A total of 15 studies met the inclusion criteria and were included in the review. The majority of studies indicated that the use of disposable medical tools was associated with a reduction in healthcare-associated infection rates, minimizing the risk of cross-contamination and microbial contamination. However, a subset of studies did not find a significant difference in infection control outcomes between disposable and reusable tools, emphasizing the importance of proper cleaning, disinfection, and sterilization protocols for reusable tools. The findings suggest that disposable medical tools may offer advantages in infection control, particularly in reducing healthcare-associated infection rates. However, the impact on quality of service outcomes remains uncertain, and the choice between disposable and reusable tools should consider factors such as infection control requirements, cost-effectiveness, environmental impact, and healthcare worker satisfaction. Proper training and adherence to cleaning and sterilization protocols are essential for the safe and effective use of reusable tools.