Preterm infants are born too earlier in time they reach their full gestational age of 40 weeks, in which the preterm infant’s loss their time, to grow in their mother womb, leads to structural and physiological immaturity. Methodology: A quasi-experimental pre and posttest control group research design was adopted in order to assess the effectiveness Kangaroo Mother Care on level of physiological parameters among preterm neonates . The independent variable of this study was Kangaroo Mother Care. The dependent variables were physiological parameters. . The study population includes preterm infants between 26-36 weeks of gestation admitted in the NICU AT SRM General hospital. The sample size consisted of 30 preterm neonates (who fulfills the inclusion and exclusion criteria) in study and control group by selected by non-probability purposive sampling technique. The study included the preterm infants who where hemodynamically stable, birth weight more than 1500 grams and admitted in the NICU. The study excluded mothers of preterm infants who were affected with contagious disease and who was not willing to provide KMC. Results and Discussion: The findings of the study revealed that KMC for 30 minutes for three consecutive days among preterm infants between study and control group, there was no significant difference in pretest level physiological parameters among preterm neonates between study and control group. Conclusion: The findings proved that the KMC for 30 minutes for three consecutive days was effectively improving the physiological parameters among preterm infants. Kangaroo Mother Care also improved the behavioral and psychological wellness of the preterm neonates