Introduction: The degree to which this approach would be effective if incorporated into the overall health care management for those with depression and long-term physical health difficulties is to date unclear. The feasibility and acceptability of the nurse-led mental health promotion intervention is addressed by many studies. This review was conducted in order to evaluate the effectiveness of nurse-led interventions on the prevention of depression among patients with chronic diseases. Methods: Eligible studies were not restricted by language to avoid language bias. We searched the following databases for eligible studies: MEDLINE (via PubMed) CINAHL PsycINFO, and Cochrane Library. Two of the reviewers independently screened the titles and abstracts to identify potentially relevant studies. Two reviewers then independently assessed their eligibility based on a full-text review. Disagreements between the reviewers were resolved by discussion to reach a consensus. Data were recorded using an Excel spreadsheet, and data extraction was performed by two reviewers independently. This was completed by two reviewers; where discussions between them did not lead to a consensus, a third assessor was involved. Results: Several meta-analyses have been performed to determine the effects of self-care interventions on people with heart failure, revealing that self-care interventions are propitious to lower hospitalization and mortality rates and improve quality of life as well as heart failure knowledge. Interventions sought for review were different and included screening, education, referral, consultation, counselling, medicine administration, complementary therapy or any psychological intervention that could be instigated within the scope of a community nurse's role. Interventions sought for review were different and included screening, education, referral, consultation, counselling, medicine administration, complementary therapy or any psychological intervention that could be instigated within the scope of a community nurse's role. Conclusions: Early detection, continuous monitoring, and support through nurse-led community service programs are essential to sustain the mental health of family caregivers. interventions for patients with chronic diseases that were led by nurses have proven effective in reducing depressive symptoms and physical symptoms, helping patients cope with physical impairments, and reducing emotional distress.