Globally, female breast cancer (FBC) is the most prevalent cancer. Chemotherapy is the main treatment of breast cancer, but it results in numerous physical and psychosocial concerns. In Kerala, Patients undergoing chemotherapy for breast cancers have varying severity of symptoms and chemotherapy may not be completed at the scheduled time. Breast cancer survivors did not routinely engage in healthy lifestyle behaviours to manage the side effects. At present there is no separate nurse run clinic to provide supportive care to patients receiving chemotherapy. So, the current study aim is to assess an effectiveness of proactive health care interventions on chemotherapy related side effects and self-care behaviour among patients with BC.