The aim of this study was to investigate the effect that a number of intracanal medications, in particular calcium hydroxide and antibiotic-steroid paste, would have on the push-out bond strength of MTA and Endocem MTA. Materials and Methods. An in-vitro experimental study was conducted on 90 extracted anterior teeth for 6 months from Jan 2022 to June 2022. The specimens were divided into 3 groups at random with 40 samples per group. Each of these groups was subdivided into two distinct subgroups. The first subgroup was utilised as a control group. The second subgroup consisted of 20 samples per subgroup. The third subgroup comprised 20 samples in each subgroup and each of these specimens was further divided into MTA (MTA) and ENDOCEM MTA with a sample size of 20. The experimental data were analysed using a quantitative research methodology that had previously been established. The data that was collected was analysed in accordance with the primary research question as well as the research methodologies that were designed to provide answers to the same. Results. It was found that the prior application of calcium hydrochloride as an intra-canal medicament improved the bonding strength of the MTA compared to the control group, which was the comparison that was made between the two. However, significantly high push-in bond strength was recorded for Endoca MTA (3.01±0.15) with the calcium hydrocloride intracanale medicament compare to (2.80±0.27) MTA, which is the comparison of the two, respectively. Conclusions. This study showed that the use of calcium silicate-based cement in regenerative endodontic procedures is beneficial in terms of enhancing the bond strength. Further in-vivo and long-term follow-up studies are required to provide evidence in support of the findings of our study.