Aim: To analyze how non surgical periodontal therapy affects the levels of serum glycated hemoglobin levels (HbA1c%, mmol/mol), C- reactive protein(CRP mg/l), interleukin 1beta(IL-1 β pg/ml) in periodontitis stage II with similar severity of disease and recognized risk factors, diabetes mellitus type 2(DM2) presenting modified grade score. Materials and Methods: 40 subjects, aged 25-60 years comprising of healthy individuals and patients diagnosed with periodontitis stage II according to the 2017 classifications were examined. A modified-grade level was assigned to the patients according to their HbA1c in DM2. The subjects were equally divided into healthy individuals (H), grade A (NDM+P), grade B (ADM+P), grade C (IDM+P).Plaque index (PI), gingival index (GI), probing pocket depth (PD mm)and clinical attachment level (CAL mm), serum HbA1c%, mmol/mol, CRP mg/l and IL-1β pg/ml were estimated at baseline and 3 months after scaling and root planning (SRP). Results: The difference in pre to post mean change in PI, GI, APD and CAL has showed significant (p< 0.001) among all the groups. The pre to post mean change showed statistically significant in both HbA1c% mmol/mol and CRP mg/l (p< 0.001) among the groups but not in IL-1β pg/ml (p = 0.552). However, it did not differ between the groups and found to be statistically insignificant. (p> 0.05) Conclusion: Non surgical periodontal therapy helps in reducing systemic inflammation and glycemic levels which in turn lowers the likelihood of developing diabetes and its complications among high risk patients.