Background: One of the reversible, efficient, globally used contraceptives is the intrauterine contraceptive device (IUCD). However, what restrict its adoption is the Lack of training, The concern about inflicting pain during the process, and complications throughout the procedure that might lead to insertion failure are the main barriers to its adoption. Aim: Our research seeks to assess the impact of vaginal misoprostol prior to LNG-IUD (Mirena®) placement on pain reduction in women who have previously had cesarean sections. Materials and method: we conducted randomized controlled study. 130 women were contacted to take part in the research. Of them, four IUD insertions failed. In all, one hundred twenty-six people were included in the analysis, sixty-four in the misoprostol trial group and sixty-two in the placebo control group. In order to decrease the frequency of unsuccessful insertions, insertion-related problems, and discomfort during insertion, the current research assessed the effectiveness of 400mcg vaginal misoprostol 6 hours before LNG-IUD insertion in women who had only had a cesarean section before.