Background and Objectives: The pathogenesis of inflammatory periodontal diseases essentially involves degradation of extracellular matrix molecules, and collagen breakdown and matrix metalloproteinases (MMPs) are proteinases primarily involved in this process. Herbal products are the recent advancement in the field of alternative medicines for the management of chronic periodontitis. They can be used as local drug delivery agents over conventional antibiotics because of their extensive natural activity, advanced safety margin, and inferior costs. The aim of this study was to to evaluate the anti-inflammatory effects of subgingival application of 1% extract from C. Sativum leaves (1% CSG) in gel form, on salivary MMP-9 (sMMP-9) levels in the treatment of chronic periodontitis.