Hyperuricemia has increased in frequency among people all over the world over the last few decades.Although homoeopathic practitioners claim that the drug URTICA URENS is being effectively used with good results clinically in the treatment of hyperuricemia , gout no relevant researches have been done to establish this , no pre-clinical studies of this drug in this has been done to the best of our knowledge Therefore there is a sincere attempt to assess the effectiveness of URTICA URENS.Allopurinol is the standard treatment for hyperuricemia. Thegoal of the study was to determine whether Urtica urens Q had hypouricemic effects in a rat model of pyrazinamide induced hyperuricemia. Male and female Wistar rats, weighing 150-200 gm were used for acute model. The blood samples were collected through retro-orbital space, and send to the lab for determination of SUA. RESULTS: Rats initial serum uric acid levels were discovered to be between 3.5 and 4.5 mg/dl. After a week daily pyrazinamide administration at a higher dose (250 mg/kg) markedly raises the blood uric acid level upto 10 mg/dl. The homoeopathic medicine Urtica urens Q at dose of 40µL/100gmPO and 30C in distilled water have comparable hypourecemic activity with that of standard drug Allopurinol. CONCLUSION. As per the observation and the results analysed from the data, homoeopathic medicine Urtica Urens has highly significant effect in controlling serum uric acid levels. The current study pyrazinamide-induced that Urtica urens Q and 30C had antihyperuricemic potential in a rat model of hyperuricemia caused by pyrazinamide.