Conventional Chest physiotherapy includes manual chest percussion, manual chest vibration, postural drainage and suctioning. The objective of this research is to determine the effectiveness of mechanical chest vibration on ventilation and oxygenation status parameters in mechanically ventilated organophosphorus poisoning patients. Material and Methods: The present study was a parallel group, randomized, controlled trial registered in Clinical Trial Registry of India (CTRI/2018/07/015074). 62 Mechanically ventilated Organophosphorus poisoning patients in medical intensive care unit of both genders of age between 20-80 years were allocated in 2 groups. Experimental group received Mechanical chest vibration by a device called G5 Vibracare along with conventional chest physiotherapy followed by suctioning for a total duration of 30 minutes twice a day. Control group consists of conventional chest physiotherapy which included manual chest percussion, manual chest vibration, and suctioning. The outcome measures evaluated in both groups were Ventilator Parameters (Static Compliance, Dynamic Compliance, VD/VT, FiO2), Oxygenation Parameters (PaO2, PaCO2, PaO2/FiO2), Quantity of secretions, and Duration of intubation were noted on day 1 and on the day of extubation. Results: Post rehabilitation the pair mean difference results observed for static compliance (10.68 vs 8.00), dynamic compliance (12.60 vs 11.04) PaO2 (-56.28 vs 11.04), VD/VT (-0.06 vs -0.05), FiO2 (-26.68 vs-24.92), quantity of secretions (-3.680 vs -3.20) following the intervention. This shows pair mean difference was more pronounced in the Experimental group compared with the Control group. Conclusion: The study concluded that the paired mean difference of Experimental Group (Mechanical chest vibration and Conventional Chest Physiotherapy) showed a improvement than the control group. Mechanical chest vibration had shown improvement in static compliance, dynamic compliance, quantity of secretions in experimental group than the control group.