Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. Most common symptoms are pain and stiffness. Most of people suffer from knee osteoarthritis. Prevalence rate of Knee osteoarthritis in India is 28%. Most common symptoms of knee osteoarthritis are pain, swelling of knee, stiffness, limited range of motion of Knee Joint. Knee joint osteoarthritis gradually hampered movement of patient. After age of 50 most of people suffer from joint pain particularly knee joint pain i.e knee osteoarthritis. On basis of Ayurvedic fundamental it can correlate with Janu Sandhigat Vata.[Knee osteoarthritis] Morbid Vata is main entity in pathogenesis of Sandhigat vata.[osteoarthritis] Basti i.e Ayurvedic medicinal enema is main line of treatment for vata. In current study effect of Shodhan Basti [Ayurvedic eliminative Enema] in management of knee osteoarthritis was assessed. Material and method – In this study shodhan basti[Ayurvedic eliminative Enema] is administered in 5 patients. First 3 oil enema [Anuvasan Basti] were given. on 4th day Shodhan Basti [Ayurvedic medicinal eliminative enema]is administered in morning followed by administration of Anuvasan Basti [Oil Enema] in evening.