Diabetes mellitus is a metabolic disorder characterized by hyperglycemia which causes serious damage to the heart, blood vessels, eyes, kidneys, and nerves. According to WHO, about 422 million people are affected by diabetes worldwide. The possible adverse reactions of present-day antidiabetic drug demand newer alternatives for the management of diabetes, improving the quality of life and prevention of diabetic complications. Objective: To evaluate the efficacy of Siddha traditional formulation Uloga Chenduram for patients with Type 2 Diabetes Mellitus Materials and methods: A non-randomized, open clinical trial was carried out on 30 patients at Ayothidoss Pandithar Hospital after obtaining approval from the ethical committee. Uloga chenduram was given to the diabetic patient for 90 days along with Triphala chooranam as an adjuvant. The efficacy of the drug was evaluated by assessing clinical symptoms, HbA1c, fasting, and postprandial blood glucose tests before and after treatment for all patients. Results: The result showed statistically significant improvement in clinical symptoms, with mean reduction in HbA1c from 10.00% to 6.8% (p <0.0073). The mean reduction in fasting, and postprandial blood glucose tests after treatment with Uloga chenduram was from 161.3mg/dl to± 24.31 to 121.56 ± 16.67mg/dl (p <0.0001) and 264.90 ± 45.47mg/dl to 200.24 ± 40.51 mg/dl (p <0.0001) respectively. Conclusion: Uloga chenduram was effective in the management of Type 2 Diabetes Mellitus in terms of its antidiabetic effects and hypolipidemic effects.