The eye is a particularly safe organ due to its structure and function. A successful treatment for eye illnesses, especially those affecting the retina and optic nerve, has been viewed as an enormous challenge. Scientists have been pushed to develop novel modes of administration such periocular channels due to the limitations of topical and intravitreal routes. Ocular medication delivery systems typically face difficulties with ocular barriers and active drug bioavailability. Microneedle, iontophoresis, dendrimers, and other applications of nanotechnology have showed promise in the treatment of ocular disorders. The development of novel delivery systems would benefit substantially from an improved knowledge of the causes, symptoms, and treatment of ocular illnesses. Future research and development efforts will focus heavily on creating non-invasive sustained medication release for treating both anterior and posterior segment eye problems.