Introduction Investigating strategies to enhance collaboration and mitigate burnout within healthcare multidisciplinary teams. Synthesizing evidence-based practices for fostering teamwork and well-being. Understanding Burnout in Multidisciplinary Teams Burnout is prevalent among healthcare professionals, impacting individual well-being, team dynamics, and patient care. Understanding its definition, prevalence, impact, and contributing factors in multidisciplinary teams is crucial for mitigation strategies. The Role of Interprofessional Collaboration in Burnout Prevention Interprofessional collaboration is pivotal in healthcare, fostering teamwork, enhancing patient outcomes, and preventing burnout among professionals. This review elucidates its significance and benefits. Strategies for Enhancing Interprofessional Collaboration This review explores diverse strategies for optimizing interprofessional collaboration within multidisciplinary healthcare teams, encompassing communication techniques, team-building activities, shared decision-making processes, and role clarity and task allocation. Assessing the Effectiveness of Collaboration Enhancement Interventions Evaluating collaboration enhancement interventions is vital for optimizing their impact on mitigating burnout and improving teamwork within multidisciplinary teams. This section explores methodological approaches, outcome measures, and evidence from existing research studies. Challenges and Barriers to Interprofessional Collaboration Identifying and addressing challenges to interprofessional collaboration (IPC) is vital for enhancing teamwork and mitigating burnout within multidisciplinary teams. This section explores organizational culture, power dynamics, and implementation hurdles. Conclusion Enhancing interprofessional collaboration (IPC) within multidisciplinary teams holds promise for mitigating burnout and improving teamwork among healthcare professionals. This study summarizes findings, discusses implications, and offers recommendations for practice and policy.