Medication safety is a critical aspect of healthcare that aims to prevent medication errors and improve patient outcomes. This article provides an overview of key factors that contribute to medication safety, including medication reconciliation, patient education, technology and automation, and collaboration and communication among healthcare professionals. Medication reconciliation plays a vital role in preventing errors during care transitions by ensuring accurate and up-to-date medication information. Patient education empowers individuals to actively participate in their medication management, fostering adherence and reducing risks. Technology and automation, such as computerized physician order entry and barcode medication administration systems, have transformed medication safety by streamlining medication processes and improving accuracy. Collaboration and effective communication among healthcare professionals are crucial, allowing for a comprehensive approach to medication safety. Strategies like interprofessional collaboration, standardized communication tools, and technology-enabled platforms enhance collaboration and communication. By incorporating these factors, healthcare organizations can minimize medication errors and enhance patient safety. Continued investment in training, education, and technological advancements is necessary to ensure the safe and effective use of medications in healthcare settings. Prioritizing medication safety initiatives can optimize patient outcomes and improve overall healthcare quality.