Background: The global landscape of public health is continuously evolving, and the recent challenges posed by infectious diseases highlight the crucial need for resilient healthcare systems. Vaccination remains a cornerstone in preventing the spread of communicable diseases. This study recognizes the significance of community engagement strategies in bolstering public health resilience, particularly in the context of enhancing vaccination uptake. Understanding the dynamics of community involvement is essential for developing targeted interventions that address barriers to vaccination acceptance. Aim: The primary objective of this research is to investigate and elucidate the role of community engagement strategies in promoting vaccination uptake. By exploring the relationship between community involvement and immunization rates, the study aims to provide insights that can inform the development of effective public health interventions. The overarching goal is to contribute to the creation of resilient healthcare systems capable of effectively responding to public health threats. Methods: A mixed-methods approach will be employed, combining qualitative and quantitative research methods. Community-based surveys, focus group discussions, and in-depth interviews will be conducted to gather data on community perceptions, beliefs, and experiences related to vaccination. The study was conducted at Khalifa Gul Nawaz Teaching Hospital/Bannu Medical College, MTI Bannu, KP. Quantitative analysis will involve statistical assessments of vaccination rates and correlations with community engagement levels. The research will be conducted in diverse communities to ensure a comprehensive understanding of the factors influencing vaccination behaviors. Results: Preliminary findings suggest a strong correlation between community engagement strategies and increased vaccination uptake. Qualitative data highlight the influence of community leaders, social networks, and tailored communication in shaping perceptions and attitudes towards vaccination. Quantitative analysis reveals statistically significant associations between community engagement initiatives and higher immunization rates. These results emphasize the importance of targeted community involvement in achieving optimal vaccination coverage. Conclusion: This study underscores the pivotal role of community engagement strategies in enhancing public health resilience through increased vaccination uptake. The findings provide valuable insights for policymakers, healthcare practitioners, and community leaders in designing interventions that foster a culture of immunization acceptance. Strengthening community ties, leveraging local influencers, and employing culturally sensitive communication are key components in building resilient healthcare systems that can effectively respond to emerging public health challenges.