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ISSN 2063-5346
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Enhancing Stability and Antifungal Efficacy of Medicated Nail Lacquer as a Drug Delivery System: Formulation, Characterization, and Evaluation

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Kajal Mishra, Sagar Bansal , Manoj Kumar Mishra , Rajat Srivastava
» doi: 10.48047/ecb/2023.12.si8.028

Abstract

The objective of this work was to harness the potential of nail lacquer as a drug delivery system to enhance the stability and antifungal efficacy of an antifungal drug. The nail lacquer formulation was thoroughly characterized, encompassing parameters such as drying time, smoothness, gloss, non-volatile oil content, viscosity, drug content, adhesion, diffusion studies, in vitro antifungal activity, and stability studies. The nail lacquer exhibited a drying time of 40 to 77 seconds, uniform smoothness and gloss, non-volatile oil content of 36±0.38 to 46±0.56, viscosity measurements between 135 and 172 centipoise, percentage drug content range of 87.55% to 98.99%, diffusion studies revealed drug release percentages ranging from 50.43% to 92.43% at 24 hours, and in vitro antifungal activity demonstrated zone of inhibition values of 7.010.56 mm and 7.980.16 mm at various concentrations

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