In-depth research into the potential of environmental chemistry to revitalise city ecosystems is presented. It delves into the relevance of environmental chemistry to the study of urban ecosystems, as well as its practical applications. The importance of environmental chemistry in detecting pollutants, developing effective mitigation techniques, and promoting successful urban redevelopment is demonstrated through an analysis of case studies from Love Canal, Cheonggyecheon stream, and the Lower Don River. The need for multidisciplinary methods, the persistence of environmental problems, the possibility of unexpected consequences, and so on are all emphasised. The article suggests that combining interdisciplinary approaches with environmental chemistry and favourable conditions is essential for effective urban regeneration. To maintain the long-term health of urban ecosystems, these results highlight the significance of coupling environmental chemistry with larger approaches to urban management.