Medication-related adverse events (MRAEs) in elderly patients present a significant challenge in emergency departments (EDs) worldwide. This review article aims to provide a comprehensive epidemiological analysis of MRAEs in elderly patients presenting to EDs. The prevalence, risk factors, clinical manifestations, and outcomes of MRAEs in this population will be discussed. Additionally, the impact of polypharmacy, drug interactions, inappropriate prescribing, and medication errors on the occurrence of MRAEs will be explored. Strategies for prevention, detection, and management of MRAEs in elderly ED patients will also be reviewed, including the role of healthcare providers, pharmacists, and technology in improving medication safety. Furthermore, the implications of MRAEs on healthcare utilization, costs, and patient outcomes will be examined. By synthesizing current evidence on MRAEs in elderly ED patients, this review aims to inform healthcare professionals, policymakers, and researchers on the epidemiology of this important issue and guide future interventions to enhance medication safety in this vulnerable population.