Head and neck cancer (HNC) are a group of malignancies involving lips, oral cavity, pharynx, ear, nose, salivary glands, para nasal sinuses and larynx. Objective: to study of epidemiological and Clinico-Pathological Characteristics of (HNC) in Clinical Oncology Department in Zagazig University Hospital. Methods: This retrospective cross sectional study was conducted in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals. All old (HNC) patients files in Clinical Oncology and Nuclear Medicine Department medical records room from (2016-2021) was included in the study. Results: the most frequent sites were oral cavity, larynx and nasopharynx (29.9%, 23.6% and 15.1% respectively). Most frequent subsites were nasopharynx (15.1%), lip (10.7%) and oral tongue (10.3%). SCC were the most frequent pathological type. Grade II was reported in 79% of the cases. PNI was present in 19.2% of the cases and LVi 4.8%. Most frequent cT was cT2 (56.1%), cN was cN2 (56.8%), AJCC clinical stage was satge II (43.2%) and pathological state was II (15.1%). CR was reported in 19.6% of the cases and OAR in 53.1% of the cases. Local recurrence was founded in 62.4% of the 133 cases and regional in 62.4% of them. Distant metastasis was founded in 19.5% and relapse in 77.8% of 135 cases while regression in 83.8% of 136 cases. Finally mortality rate was 52%. There was a statistical significance increase in NR, local recurrence, distant metastasis, relapse and progression response among dead compare to lived cases. There was a statistical significance increase in median overall survival among cases less than 50 years old, stage II AJCC, CR cases and cases with absent local recurrence. Conclusion: Head and neck cancer is a major health problem in Zagazig, and its incidence is increasing. The high prevalence of tobacco consumption and HPV infection makes screening programs, and the surveillance of those patients represents a very important tool for early detection of HNC cases.