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ISSN 2063-5346
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Epidemiological and clinicopathological profile of triple negative breast cancer at a tertiary cancer centre in Rajasthan: A three-year experience

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Samarth V Dave, Sanjay Sharma, Dinesh Yadav, Neha Sethi, Nitin Khunteta, Anand Mohan, Mrinal Das, Mohinder Viswanath, Raj Govind Sharma, Akash Mishra
» doi: 10.48047/ecb/2023.12.11.22

Abstract

Triple negative breast cancer (TNBC) has attracted the attention of oncologists and pathologists because of its aggressive nature and lack of targeted therapy. Ample research has been reported in western literature on TNBC, all concluding poor prognostic features in comparison to other molecular subtypes. However extensive research from India is lacking. Objectives: To study epidemiological and clinicopathological profile of TNBC. Materials and Methods: This is a retrospective study of all cases of breast carcinoma enrolled in the department of surgical oncology and oncopathology at MGH,Jaipur between 2020 and 2023. Out of all the cases, 107 cases of TNBCs were included in the study and analysed. Results: The median age at presentation was 54 years. Most of the patients were post- menopausal with no significant risk factors or family history. 5th and 6th decade were the commonest age at presentation. Most of the patients were multipara, only 10 patients (9.5%) were nullipara. Family history was positive in 8.4% cases. Infiltrating ductal carcinoma- NOS type was the most common histology (69.5%). Most of the tumors were of poorly differentiated variety (55.7%). 40.2% cases were in stage IIA. The patients showed good response to neoadjuvant chemotherapy with many of them showing complete pathological response (41%). Relapses were more common in non-responder group. Recurrences were mainly visceral relapses. Locally advanced stage and lymph node positivity showed poorer RFS and OS. Conclusion: TNBC are very aggressive cancers that have marked epidemiological, pathological and prognostic characteristics. Around 18% of breast carcinoma reported at our institute were TNBCs. They are highly chemoresponsive and yet they have poorer outcomes. Still longer follow-up is necessary for more definite data on TNBCs.

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