One of the most prevalent malignancies in women and a leading cause of death in breast carcinoma. Breast cancer death rates are predicted to be approximately 90,408 (10.6%) and new cases to be around 1,78,361 (13.5%), respectively, in India, according to Globocan 2020. The prognosis and treatment of breast cancer depend on a number of factors, including the size of the tumour and the lymph node metastases, the presence of hormone receptors, and the histological grade. Objective: The purpose of this study is to examine the association between the human epithelial growth hormone receptor (HER2/neu) status and the oestrogen receptor (ER), progesterone receptor (PR), and progesterone receptor status in various histological grades of breast cancer. To determine the association between the proliferation status and the major prognostic variables. Methods: From January 2020 to May 2022, a cross-sectional study was carried out at the recognised laboratory NABL (National Accreditation Board for Testing and Calibration Laboratories) at the Department of Pathology, JSS Hospital, Mysuru. In order to get thin sections from the laboratory of women who had undergone a mastectomy or core biopsy after being diagnosed with breast cancer, the study employed 100 paraffin blocks.