Objective: The objective was to evaluate the anti-inflammatory and antiarthritic activity of Polyherbal tablet formulation in Histamine-induced arthritis in rats. Materials and Methods: The antiarthritic activity and pro inflammatory cytokines inhibition by Polyherbal tablet formulation was evaluated using Histamine-induced arthritis models, at doses of 100, 200 mg/kg body weight. The anti-inflammatory activity of Polyherbal tablet formulation of was assessed using a digital plethysmometer in the Histamine induced paw edema model. Paw volume were measured at regular intervals using a micrometer screw gauge. Serum samples were collected for the estimation of proinflammatory cytokines. Diclofenac (20 mg/kg body weight) was used as the standard drug in both models. Acute and chronic toxicity studies were conducted to assess the safety of the test drug.