The most hopeful chance to stop the global COVID-19 pandemic has come from the introduction of COVID-19 vaccinations. The COVID-19 vaccines, however, have been connected to severe side effects and increased blood indicators. This is a prospective study investigating the impact of different pfizer vaccine on inflammation markers (IL-1b and IL-10) along with blood markers among the vaccinated and controls (no vaccination). The study included 70 vaccinated individuals and 25 non-vaccinated healthy controls. Blood glucose levels, Triglycerides, HDL, LDL, WBC count, Lymphocyte count, haemoglobin, platelet count, cholesterol and D-dimers were estimated and measured using the Cobas c 111® clinical chemistry automated system. The main findings where that vaccinated individuals (both doses) enhanced inflammation and platelet activation. We found a strong correlation between vaccination and both IL-1β and IL-10 (p<0.01). Spearman rank correlation analysis showed that IL-1β was directly proportional to doses within the plasma (r = 0.55132, P < 0.001). We also found IL-10 levels to be elevated with vaccination in the serum in all the subjects (p<0.01). However there is no significant comparison seen between the male and female subjects (p<0.01). In the event that vaccinated experience a more evident and severe COVID-19 clinical course, this may help to ensure the best possible vaccine response