To determine the level of salivary lactate dehydrogenase(LDH) in oral submucous fibrosis (OSMF), oral lichen planus (OLP) and lichenoid reaction (LRs). METHODS: Clinically diagnosed 90 cases of OSMF, OLP and LRs were considered and 30 healthy individuals were considered as control group to compare the salivary LDH levels. Unstimulated saliva (2ml) was collected in aseptic conditions and was processed for estimation of salivary LDH. RESULT: The results showed a positive relation of increased levels of salivary LDH between the OSMF and OLP & LRs participants and healthy individuals with statistical significance. Thus, justifying the belief that levels of salivary LDH can be utilized in early detection of OPMDs and making salivary LDH level estimation a potential noninvasive alternative to other invasive procedures for diagnosis.