Purpose- The purpose of the study is to explore the ethnomedicinal knowledge and phytochemical analysis of Schleichera Oleosa (Kusum) as a potential resource for treating skin diseases in Odisha, India. The study aims to document traditional knowledge related to skin diseases and investigate the presence of secondary metabolites in the bark.Methods- The methods employed in the study include ethnomedicinal surveys, collection of plant specimens, phytochemical analysis using various techniques, and documentation of traditional knowledge related to skin diseases.Results- This study explores the ethnomedicinal knowledge and phytochemical analysis of Schleichera Oleosa (Kusum) as a potential resource for treating skin diseases in Odisha, India. Phytochemical analysis of Schleichera Oleosa bark shows the presence of tannins, flavonoids, saponins, alkaloids, oxalates, and cyanogenic glycosides, contributing to its antimicrobial properties and potential therapeutic benefits. Conclusion- In conclusion, this study contributes to the documentation of ethnomedicinal knowledge in Odisha, India. The presence of various phytochemicals in Schleichera Oleosa bark, such as tannins, flavonoids, and alkaloids, highlights its potential as a natural source of antimicrobial compounds for further exploration and development