To investigate the importance of High sensitivity C reactive protein in predicting the risk of Coronary Artery Disease in Type II Diabetes Mellitus patients. MATERIALS AND METHODS: This research was carried out at Supa Hospital, Cardiac Care Centre, Dharmapuri, and Meenakshi Medical College Hospital & Research Institute, Kanchipuram, Tamil Nadu. A total of 60 individuals consist of 20 apparently healthy individuals, 20 Type II Diabetes Mellitus patients (T2DM) and 20 T2DM patients diagnosed with Coronary Artery Disease (CAD) were selected for this research. Anthropometric measurements as well as resting blood pressure were taken along with detailed clinical history. All fasting lipid profiles were analysed using Chemwell 2910 Automated EIA and chemistry analyser. ELISA was used to measure high sensitive C reactive protein (hs-CRP) with a coefficient of variation under 5%. RESULTS: This research provides a comprehensive review of current knowledge concerning risk of developing CAD, in evaluating the hs-CRP levels and concludes with a risk assessment of coronary artery disease based on evidence for hs-CRP. To conclude, When compared to normal and T2DM subjects, hs-CRP levels in T2DM patients with CAD were shown to be considerably higher. (Key words: Coronary Artery Disease, T2DM, hs-CRP, Atherosclerosis, Lipid Profile, Blood Pressure).