Aim: This study aims to assess the efficacy and utility of comprehensive physical assessment protocols in improving the care and outcomes of mechanically ventilated children within a tertiary care hospital. Background: Mechanically ventilated children often require specialized care due to the complexity of their medical conditions. Comprehensive physical assessment protocols can play a pivotal role in enhancing the management of these patients. However, there is a paucity of research evaluating the impact of such protocols on the care and outcomes of mechanically ventilated children in tertiary care settings. Methods: This prospective study was conducted over a 12-month period, involving mechanically ventilated children admitted to a tertiary care hospital. A multidisciplinary team of healthcare professionals developed and implemented comprehensive physical assessment protocols tailored to the specific needs of this patient population. The study assessed the adherence of healthcare providers to these protocols, monitored the impact on clinical care, and analyzed relevant patient outcomes, such as ventilator-associated complications, length of hospital stay, and mortality rates. Results: The implementation of comprehensive physical assessment protocols significantly improved the quality of care provided to mechanically ventilated children in the tertiary care hospital. Adherence to these protocols resulted in a reduction in ventilator-associated complications, shorter lengths of hospital stay, and improved overall patient outcomes. Healthcare providers reported increased confidence and competence in managing these complex cases, and patients and their families expressed higher satisfaction with the care received. Conclusion: Comprehensive physical assessment protocols are a valuable addition to the care of mechanically ventilated children in a tertiary care hospital. This study demonstrates their efficacy in enhancing the quality of care, reducing complications, and improving patient outcomes. Implementation of such protocols should be considered a standard practice in the management of these vulnerable pediatric patients.