Background: RAS (recurrent aphthous stomatitis is a painful condition affecting the oral cavity and presents as shallow oral ulcers surrounded by the erythematous halo with a high recurrence rate and posing difficulties in speech and mastication. Aim: The present study aimed to assess the efficacy of 2% curcumin oral paste to 5% topical Amlexanox in management of the recurrent aphthous stomatitis concerning the recurrence rates, pain scores, erythema, and ulcer size. Methods: 96 subjects were assessed and divided into two groups where Group I subject were managed with 2% curcumin oral gel and 48 subjects for Group II with 5% Amlexanox oral paste. Subjects were assessed at 1, 4, and 7 days for pain score, erythema level, and ulcer size. The ulcer recurrence was evaluated at 30, 60, 90, and 180 days and results were formulated. Results: The study results showed a significant reduction in pain scores and erythema with curcumin use in Group I with respective p-values of 0.01 and 0.03. The ulcer size was reduced in both groups with a nonsignificant difference. A higher recurrence rate was seen for Group II subjects using Amlexanox compared to Group I where curcumin was used. Conclusion: The present study concludes that curcumin is a safe and potent substitute for managing recurrent aphthous stomatitis concerning the reduction of recurrence rates, pain, and erythema. However, further studies are needed to assess the efficacy of curcumin in different types of recurrent aphthous stomatitis.