Poisons are compounds that when ingested, absorbed, injected or inhaled cause disruption of normal body functions usually through chemical reactions or activities on the molecular scale. Over the exposure time, the concentration of poison in the body can build up, it can redistribute, or it can overwhelm repair and removal mechanisms. The purpose of this study was to assess the affect of poison on the hepatic functioning. The psychiatric counselling and diet changes are essential as a part of the treatment. The main aim of the study is to evaluate and assort the hepatic failure risk among the various poisoned cases. Evaluation and Assortment of Hepatic Failure Risk among various Poisoning Cases in the Department of General Medicine in Tertiary Care Teaching Hospital for a period of 6 months(October 2021 – March 2022). The study was conducted after obtaining ethical clearance from the Institutional Ethical Committee. All the data under the inclusion criteria are included and assessed. The data was collected in the designed data collection form (including lab profile before counselling and after counselling) using CHILD-PUGH Score. A total of 250 subjects met the inclusion criteria of the study. Based on the CHILD-PUGH Score, the percent of 1-year survival rate staging was done. Before counselling(on day-3), 158(63.20%) of cases were under Class-A(100% 0f 1-year survival rate) followed by 91(36.40%) of cases under Class-B(80% of 1-year survival rate) and 1(0.4%) of cases under Class-C(45% of 1-year survival rate). Two months after counselling, 194(77.60%) of cases were under Class-A followed by 55(22.00%) of cases under Class-B and 1(0.4%) of cases under Class-C. The obtained results were analyzed using Chi-Square test and ‘p value’of p = .0011 was obtained in view of developing hepatic failure, our data showed that there is a good statistical significance between poisoning and hepatic failure risk. The results also revealed that there is a reduction in the risk after providing counselling(followup: 2 months), “p value” of p = .001875 was obtained.