In order to treat the pathogenic bacterium, new medications must constantly be created. In this study, imidazole tablet physicochemical properties were investigated while various heterocyclic compounds were converted into 5-nitroimidazole derivatives. The nitroimidazole antibiotic drug metronidazole, technically known as 2-(2-methyl-5-nitro-1Himidazol-1-yl) ethanol, is used mostly for anaerobic bacteria and protozoa. Antibiotic, amebicide, and antiprotozoal all describe metronidazole. It is the medication of choice for mild-to-moderate Clostridium difficile infection initial episodes. In paper shows the results of quality control tests on four different Metronidazole generic products and four different brand-name products. The results are summarised as an average value for tablet hardness, weight uniformity, friability percentage, average time of disintegration test, and percentage of Metronidazole content in each sample product. Medicinal chemistry focuses on the development, identification, and interpretation of the chemical mechanisms underlying the biological activity of substances, using Manihot ultilissima starch, metronidazole tablets were made with good compact (9–10 Kgf hardness) and minimal friability.