Introduction: Infrazygomatic Crest Bone Screws are break through in the world of orthodontics for anchorage reinforcement. The size of the Bone screws and the site of placement depend on the bone thickness in the infrazygomatic crest area. Objective: To evaluate and compare the bone thickness and insertion height at 45°, 50°, 55°, 60°, 65°, and 70°angulation in infra-zygomatic crest region. Methods: The infrazygomatic crest bone thickness was evaluated on 22 patients using cone beam computed tomography. The measurements were made along the distobuccal root of maxillary first molar at different angulations ranging from 75 to 40 degrees to the occlusal surface of the molar. Results: Infrazygomatic crest bone thickness is 4.5 mm to 9 mm when measured at an angle of 40° to 70° to the maxillary First molar occlusal plane and 10 to 17 mm above the occlusal plane. The best possible site for bone screw insertion is 10 to 14mm above the occlusal plane at an angle of 65° to 70°. Application: helps the clinician to accurately place the infrazygomatic crest bone screw for various orthodontic treatments. Reduces the failure rate of the infrazygomatic crest bone screw. Reduces the risk of damage to surrounding structures