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ISSN 2063-5346
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Evaluation of Anti-abortifacient Activity from Methanolic Extract of Withania somnifera in Misoprostol Induced Female Wistar Rats

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Md Kabirul Islam Mollah, Biplab Debnath, 2 Shalini Das, Kishor Kumar Roy
» doi: 10.31838/ecb/2023.12.si7.517

Abstract

Abortion is the termination of a pregnancy by removal or expatriation of an embryo or fetus. According to WHO, revocation is a common health intervention. But currently, it has come a major issue that substantially women suffer confinement during early or late pregnancy. It has been suggested that some women who misfire may not make enough progesterone in the early part of pregnancy. Supplementing these women with specifics that act like progesterone (these are called progestogens) has been suggested as a possible way to help intermittent confinement. Misoprostol which is chemically known as 7-((1R, 2R, 3R)-3-hydroxy-2-(4- hydroxy-4-methyloct-1-enyl)-5-oxocyclopentyl) heptanoic acid methyl ester is a prostanoid, which induces labor, beget an abortion. For abortions it's used by itself and with mifepristone or methotrexate. By itself, effectiveness for abortion is between 66 and 90. For labor induction or abortion, it's taken by mouth. Withania somnifera (Family Solanaceae), generally known as ashwagandha (winter berry) have been reported to be useful in abortion worldwide and but at a great extent can be used as anti-abortifacient and colorful other remedies. W. somnifera is also rich in multitudinous valued secondary metabolites similar as steroids, alkaloids, flavonoids, phenolic, saponins, and glycosides. A wide range of preclinical trials similar as cardio protective, anticancer, antioxidant, antibacterial, antifungal, anti-inflammatory etc.

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