A metabolic condition with numerous aetiologies is diabetes mellitus. In addition to problems in protein, fat, and fat metabolism that impact insulin output and action, it is characterised by persistent hyperglycaemia. Diabetes mellitus results to inappropriate and increased hyperglycaemia conditions. Protein glycation is another main reason for the complications of diabetes Advanced glycation end products are created when proteins are glycated, altering the structure of the protein and its enzymatic activity. In some individuals improper glycaemic control can be brought about by exercise, reduction in body weight, and reducing oral glucose levels. Long term complications of diabetes can lead to loss of vision; neuropathy which leads to renal failure, ulcers in the foot, genitourinary and cardiovascular diseases. One of the main causes of diabetes in the world's population is the absence of modern medical services. The goal of current review is to identify the pharmacological applications of several medicinal plants. Allicin, cysteine, sulfoxide, and s-allyl cysteine sulfoxide, cyaniding glycosides, quercetin, flavonoids, sterols, phenols, prostaglandins, lignin, saponins, anthraquinones, alkaloids, glycosides, steroids, phenolics, and tannins are among the chemical constituents found in high concentration in these medicinal plants. Examples of Medicinal plants which are used for the anti-diabetic activity are Alliumcepa, Alliumsativum, Aloe vera, Momordicacharantia, Ocimumsanctum, Panax ginseng, Cinnamomunverum, Psidium guajava, Brassica juncea, Capsicum annum etc. due to their phytochemical constituents and biologically active components which shows beneficial effects.