This study's goal is to determine the role of Trigonella foenum-graecum (fenugreek) extract of seeds on hyperuricemia as well as on the kidneys of hyperuricemic rats which were induced combined dose of ethambutol 250 mg/kg and adenine 100 mg/kg and this was treated by the extract of Trigonella foenum-graecum with a higher dose of 500 mg/kg along with a lower dose 250 mg/kg and the std. drug allopurinol 10 mg/kg for 21 days one-hour next of induced dose administered intragastrically and the different biochemical parameter was evaluated on 21 th day UA in serum, BUN, and CRE, and on the same day the rats were sacrificed. TFGE administration reduced the concentrations of UA, BUN, as well as CRE in serum meanwhile treatment with TFGE reverse the accumulated uric acid crystal in the kidney which was determined by the histopathological study of kidneys.